Similac
360 Total Care Sensitive
Our verdict
For babies whose issue is lactose rather than protein, this delivers Similac's full 5-HMO, no-palm-oil package in a low-lactose recipe. Two honest caveats: its carbs are corn syrup plus added sugar, and constipation is the most recurring complaint in parent reviews. Works beautifully for some babies; know which lever it actually pulls (lactose, not protein).
Score breakdown
What's great
- Only sensitive formula in this set with a 5-HMO prebiotic blend
- No palm olein oil in the fat blend
- Widely available including large value cans (30.2, 34.9, 40 oz) that lower per-ounce cost
- Ready-to-feed bottles available (32 fl oz and 2 fl oz nursettes)
Worth knowing
- Protein is intact (not hydrolyzed), so it targets lactose sensitivity, not protein digestion
- Contains both corn syrup and added sugar (sucrose) as carbohydrates
- Among the pricier mainstream sensitive formulas; parents frequently flag the cost
- Contains milk and soy ingredients
What's in it
| Protein | Milk protein isolate (intact protein, NOT hydrolyzed) |
| Carbs | Corn syrup and sugar (sucrose); marketed for lactose sensitivity - lactose is not a listed major ingredient |
| Fats | High-oleic safflower oil, soy oil, coconut oil; no palm olein oil; DHA included (no palm oil) |
| Key features | Exclusive blend of 5 HMO prebiotics (2'-FL, 3-FL, LNT, 3'-SL, 6'-SL) structurally identical to those in breast milk · No palm olein oil - associated with softer stools and better calcium absorption in Abbott's cited research · DHA, lutein, and vitamin E blend for brain and eye development · Iron-fortified · No artificial growth hormones |
| Stage | 0-12 months |
| Forms | powder, ready-to-feed |
| Where to find it | Very widely available: Amazon, Walmart, Target, Costco, Sam's Club, Safeway/Albertsons chains, abbottstore.com; powder in 20.1 oz tub and 30.2/34.9/40 oz cans; ready-to-feed 32 fl oz bottles and 2 fl oz nursettes |
Note: Price derived from Similac.com case pricing: $329.82 for a case of six 30.2 oz cans = $54.97/can (Aug 2026); Walmart single-can pricing is typically similar. ASIN B0BLCWJC44 (30.2 oz tub) seen in amazon.com/dp URL; a 34.9 oz 3-pack listing B09F5FHFPC was also seen. Kosher and Halal certified per Target listing.
Best for
What parents say
Recurring themes we found across public parent discussions (Walmart customer review pages (walmart.com/reviews/product/862052967, /774464680, /450756312), Sam's Club member reviews for 40 oz Sensitive powder (samsclub.com/reviews/product/13865050283), JustAnswer pediatrics thread on Similac Sensitive and constipation) — not reviews submitted on this site.
Loved
- Many parents report a large reduction in gas and congestion after switching from routine or older Similac Sensitive versions
- Described as gentle on the stomach with mix described as smooth/close to breast-milk consistency
- Often recommended or started in hospitals, which builds trust; ~4.7-star average across major retailers
Common complaints
- Constipation is the most recurring complaint; some babies needed intervention or a formula change
- Price described as 'outrageous' by multiple reviewers
- Some babies who did fine on regular 360 Total Care got fussier on Sensitive (individual variation)
Common questions
What's the difference between Similac 360 Sensitive and Enfamil Gentlease?
They pull different levers: 360 Sensitive keeps intact milk protein but removes most lactose; Gentlease breaks the protein into smaller pieces AND reduces lactose. A baby struggling with protein digestion may do better on Gentlease; one struggling with lactose may do better on Sensitive.
Does Similac 360 Sensitive cause constipation?
Constipation is the most commonly reported complaint for this formula in retail reviews. Not all babies experience it, but it's worth watching for during the first two weeks.
Is Similac Sensitive lactose-free?
It's marketed for lactose sensitivity and lactose is not a major listed ingredient — but it is not certified lactose-free. Truly lactose-free needs are usually met with soy or specialty formulas under pediatrician guidance.
Reviews from parents like you
Real submissions from readers — moderated for spam, never edited for opinion.
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