Similac
Soy Isomil
Our verdict
The better-composed of the two big soy formulas on fat — no palm oil, and cheaper per ounce than ProSobee — but it adds table sugar (sucrose) to its corn-syrup carb base, which many parents specifically avoid. Same narrow AAP-supported use cases as all soy formulas; between the two giants, your priorities (palm oil vs added sugar) pick the winner.
Score breakdown
What's great
- No palm olein oil — a differentiator vs Enfamil ProSobee for parents avoiding palm oil
- Slightly cheaper per ounce than ProSobee at typical retail prices
- Fully milk-free and lactose-free from a major FDA-regulated US brand
- Wide retail availability and multiple formats
Worth knowing
- Carbohydrates are corn syrup solids plus added sugar (sucrose ~10%) — Isomil contains added table sugar, which some parents specifically avoid
- AAP limits routine soy formula use to specific situations (see notes)
- Not first choice for cow milk protein allergy (soy cross-reactivity in 10-14% of milk-allergic infants)
- Not organic or non-GMO
What's in it
| Protein | Soy protein isolate (plant-based; milk-free) |
| Carbs | Corn syrup solids and sugar (sucrose); lactose-free |
| Fats | High oleic safflower oil, soy oil, coconut oil (no palm olein) (no palm oil) |
| Key features | Soy-based, lactose-free, milk-free formula · No palm olein oil (Abbott/Similac's standard fat blend) · OptiGRO blend: DHA, lutein, and vitamin E · Marketed for fussiness and gas when switching from milk-based formula · Powder, concentrated liquid, and ready-to-feed formats |
| Stage | Infant, 0-12 months |
| Forms | powder, concentrate, ready-to-feed |
| Where to find it | Walmart, Kroger, CVS, Target, Amazon, similac.com/Abbott Store; commonly WIC-eligible |
Note: Same AAP soy guidance applies as ProSobee: indicated for galactosemia and congenital lactase deficiency, acceptable for vegan-preference families; not recommended routinely for colic or cow milk protein allergy. Ingredient percentages per retailer listing: corn syrup solids ~39%, soy protein isolate ~15%, high oleic safflower oil ~11%, sugar (sucrose) ~10%, soy oil ~8%, coconut oil ~8%. Key factual difference vs ProSobee: Isomil has no palm olein but contains added sucrose; ProSobee has palm olein and no sucrose. Price basis: Walmart lists the 30.8 oz value can at $42.84 (~$1.39/oz); a 12.4 oz can and 32 fl oz ready-to-feed are also sold. Verified ASIN B085YQJJPH is the 30.8 oz powder (4-pack listing) seen in an amazon.com/dp URL; a ready-to-feed 32 fl oz /dp URL (B00SWV92YO) was also observed.
Best for
What parents say
Recurring themes we found across public parent discussions (https://www.walmart.com/reviews/product/680018024, https://www.walmart.com/reviews/product/15610746, https://www.cvs.com/shop/similac-soy-isomil-for-fussiness-and-gas-infant-formula-powder-1ct-prodid-212243-reviews, https://www.influenster.com/reviews/similac-soy-isomil-infant-formula-for-fussiness-and-gas-powder-145-lb) — not reviews submitted on this site.
Loved
- Many parents report dramatic reduction in gas, crying, and colic-like fussiness within days of switching
- Reports of spit-up/vomiting improving after the switch
- Described as gentle on the stomach for lactose-sensitive babies
Common complaints
- Results are inconsistent — helps some babies, does nothing for others
- Some parents object to the added sugar (sucrose) and corn syrup solids in the ingredient list
- Occasional reports of constipation/firmer stools, typical of soy formulas
Common questions
What's the difference between Isomil and ProSobee?
Two clean trade-offs: Isomil has no palm oil but contains added sucrose; ProSobee has palm oil but no sucrose. Both are soy-protein, lactose-free, corn-syrup-based formulas from FDA-regulated brands.
Is Isomil good for gas and fussiness?
Abbott markets it for fussiness and gas when switching from milk-based formula, and some parents report dramatic improvement — but the AAP doesn't recommend soy formula for routine fussiness or colic, so treat this as a pediatrician conversation, not a shelf experiment.
Does Isomil contain lactose?
No — it's fully lactose-free and milk-free, using corn syrup solids and sucrose as carbohydrates.
Reviews from parents like you
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