Our verdict
The most complete prebiotic package in a mainstream US formula, with no palm oil and hospital-brand familiarity. You pay a premium for it, and the powder is a notorious foamer — swirl, don't shake. If your baby started on Similac at the hospital and is doing well, there's no reason to leave.
prices re-checked weekly · updated Aug 29, 2026
Score breakdown
What's great
- Only mainstream US formula with a 5-HMO prebiotic blend
- No palm olein oil in the fat blend
- Widely available at virtually every US retailer (Walmart, Target, Amazon, grocery, pharmacy)
- Available in powder and ready-to-feed (2 oz, 8 oz, and 32 oz bottles)
- Abbott is the #1 hospital brand, so many babies start on Similac at the hospital
Worth knowing
- One of the most expensive mainstream formulas (about $1.40-$1.62/oz of powder)
- Reviewers report it takes a lot of shaking to fully dissolve and foams noticeably after shaking
- Contains soy oil (a concern for some parents)
- Abbott's 2022 Sturgis plant recall (historical) shook some parents' trust and caused past availability gaps
What's in it
| Protein | Nonfat milk and whey protein concentrate (cow's milk based) |
| Carbs | Lactose |
| Fats | High oleic safflower oil, soy oil, coconut oil (no palm olein oil) (no palm oil) |
| Key features | 5 HMO prebiotic blend (2'-FL, 3-FL, LNT, 3'-SL, 6'-SL) - the broadest HMO blend in a mainstream US formula · DHA, lutein, and vitamin E for brain and eye development · No palm olein oil (Abbott cites softer stools and calcium absorption) · Iron-fortified · Non-GMO ingredients |
| Stage | 0-12 months |
| Forms | powder, ready-to-feed |
| Where to find it | Nationwide: Walmart, Target, Amazon, Costco, grocery and drug stores; powder tubs (20.6 oz), value cans (30.8 oz), and ready-to-feed bottles |
Note: ASIN B0BL638W1W is the 20.6-oz powder tub listing (seen in amazon.com/dp URL). Walmart price $49.97 for the 30.8-oz value can ($1.62/oz); NewModernMom measured about $1.40/oz at Costco, so per-oz cost varies by retailer. A Sensitive version exists but this entry covers the standard cow's-milk version.
Best for
What parents say
Recurring themes we found across public parent discussions (Walmart.com customer reviews (product 851227148), Slickdeals deal threads and comments on Similac 360 Total Care, NewModernMom Bobbie vs Kirkland vs Enfamil vs Similac hands-on comparison, TeachToddler and BabyPost Similac 360 vs Enfamil NeuroPro comparisons (2026), Note: direct r/FormulaFeeders threads did not surface in web search results; themes are from the public review sources above) — not reviews submitted on this site.
Loved
- Babies started on Similac at the hospital keep taking it at home without a fight
- Softer stools attributed to the no-palm-oil fat blend
- Perceived immune/digestive benefit from the 5-HMO blend
- Easy to find in stores and in ready-to-feed form for travel and night feeds
Common complaints
- Price - frequently called out as the most expensive mainstream option
- Foaming and slow dissolving when shaken; some parents let bottles rest or swirl instead
- A few parents report gassier babies on the ready-to-feed version vs the powder
- Lingering wariness from the 2022 Abbott recall
Common questions
Is Similac 360 Total Care the same as what hospitals give?
Abbott (Similac's maker) is the largest hospital formula supplier in the US, and 360 Total Care is its flagship routine formula — so many babies do start on Similac in the hospital, so keeping the same formula at home is usually the path of least resistance.
Why does Similac 360 Total Care foam so much?
The powder is prone to foaming when shaken hard. Many parents swirl the bottle instead of shaking, or prepare bottles a few minutes early to let the foam settle.
Does Similac 360 Total Care contain palm oil?
No — it uses safflower, soy, and coconut oils. Abbott's formulas skip palm olein, which the company links to softer stools and better calcium absorption.
Reviews from parents like you
Real submissions from readers — moderated for spam, never edited for opinion.
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